Fever on the soles of the feet is mostly caused by yin deficiency and can be treated with general treatment (adequate rest) and medication (Zhi Bai Di Huang Wan), but there is no fastest and most effective way. 1. General treatment: Fever on the soles of the feet belongs to the category of heat in the five centers of the heart, which is mostly caused by deficiency of yin and heat. In daily life, patients should ensure sufficient rest, maintain a light diet, eat more fruits and vegetables, and avoid eating greasy food such as barbecue. 2. Medication: Qi Ju Di Huang Wan is composed of Chinese wolfberry, Radix Rehmanniae Praeparata, Chinese yam and other medicines, which has the effect of nourishing the liver and kidney, and can treat dizziness, blurred vision, lumbar and knee soreness and weakness (the feeling of lumbar and knee soreness and weakness), and five heart-quenching heat (the heart of the two hands and the two hearts of the two feet are hot, and conscious of the heart and chest heat) and so on, which are caused by the deficiency of yin in the liver and kidney. Zhi Bai Di Huang Wan is composed of Zhi Mu, Huang Bai, Dan Pi, etc. It has the efficacy of nourishing yin and lowering fire (nourishing yin essence and lowering fire), and can treat night sweating (abnormal sweating after going to sleep, and stopping of sweating after waking up), five heartburns and heat and spermatorrhea caused by yin deficiency and fire (deficiency of yin essence and the emergence of hyperactive deficiency fire in the body). Its contraindications and adverse reactions are not yet clear. All of the above treatment options are effective, but the fastest and most effective option does not exist. If medication is needed, it should be administered under a doctor’s supervision. If the symptoms are more serious, please go to the hospital in time, do not delay the condition.