Thyroid parenchymal echogenicity is a manifestation of thyroid ultrasound, indicating that the density inside the thyroid gland is uneven, which can be seen in Graves’ disease, autoimmune thyroid disease, thyroid nodules and other diseases, and should be perfected with relevant examinations, and then take corresponding treatments after a clear diagnosis. 1. Graves’ disease: diffuse thyroid lesions can be seen, and there may be uneven echogenicity of the thyroid parenchyma, which can be treated with antithyroid drugs such as methimazole, as well as radioactive iodine therapy and surgical treatment. 2. Autoimmune thyroid disease: such as Hashimoto’s thyroiditis, symptomatic treatment can be taken according to thyroid function and clinical manifestations. 3. Thyroid nodules: thyroid nodules are divided into benign nodules and malignant nodules, benign nodules can be observed and thyroid ultrasound should be checked regularly; malignant nodules should be treated with surgery in time. Patients with uneven echogenicity of thyroid parenchyma should go to the hospital in time to find out the cause and treat according to the etiology.