Cold hands and feet without high fever may be caused by pathologic factors such as upper respiratory tract infections, neurodevelopmental abnormalities, and toxic encephalopathy. 1. Upper respiratory tract infection: Upper respiratory tract infection may cause high fever, and there may also be a cold body. After the high fever subsides, the body’s immune system does not return to the normal level, and the upper respiratory tract infection has not yet fully recovered, which may cause the body to be more sensitive, and then cold hands and feet may occur. 2. Abnormal development of the nervous system: fever may cause the autonomic nervous system of vasodilatation and contraction to be disorganized, and abnormal development of the nervous system may still occur after the fever has subsided. Abnormalities in the development of the nervous system may cause disruption of blood flow and lead to this phenomenon. 3. Toxic encephalopathy: Viruses may breed and multiply in the brain, causing intracranial infections, which in turn affect the blood circulation in the brain, resulting in the symptom of high fever that does not go away. Toxic encephalopathy affects the blood circulation of the body, resulting in abnormal peripheral nerve function, abnormal blood circulation in the hands and feet, which in turn leads to cold hands and feet. Patients with high fever and cold hands and feet need to go to the hospital in time to see a doctor, identify the cause of the disease, and then give targeted treatment.