Gastric sinus biopsy is mainly used to determine benign and malignant diseases of the stomach and can be used to rule out malignant tumors. Gastric sinus biopsy is a pathologic section of the gastric mucosal tissue. In the gastroscope into the stomach to take the gastric sinus part of the mucosal tissue, through the microscope to observe the morphology of the tissue cells and glandular changes. Gastric sinus biopsy is mainly used to diagnose the degree and nature of mucosal damage in the gastric sinus, and is the gold standard for determining benign and malignant diseases of the stomach. In clinical practice, it is indicated for patients with chronic gastritis, gastric ulcer, and suspected malignant tumor lesions. Gastric sinus biopsy may cause nausea, vomiting symptoms, before the examination need to be psychologically prepared to cooperate with the operation of the physician, after the examination by a professional physician to determine the specific results of the examination.