People with poor immunity can receive the new coronavirus vaccine if there are no contraindications to vaccination. People with relatively low immunity have a higher risk of developing various infectious diseases than the general population, especially the new coronavirus, which is generally susceptible to the population, so people with poor immunity should be vaccinated with the new coronavirus vaccine. If there are no contraindications for the following, it is possible to receive the new coronavirus vaccine. 1. People who are allergic to the active ingredients of the vaccine or people who have been allergic to the same type of vaccine in the past. 2. Persons with uncontrolled epilepsy and other severe neurological disorders (e.g., transverse myelitis, Guillain-Barre syndrome, demyelinating diseases, etc.). 3. Persons who are experiencing fever, or suffering from acute illness, or acute exacerbation of chronic illness, or uncontrolled severe chronic illness. 4. Women during pregnancy. However, it does not mean that people with poor immunity will be completely prevented from infection after vaccination with the New Crown vaccine, but it can prevent the spread of New Crown to a certain extent. It is still necessary to take appropriate protective measures after vaccination with the New Crown Virus vaccine, such as wearing masks, washing hands frequently, gathering less and ventilating the air frequently in order to reduce the risk of infection.