Diagnosis of Major syndrome usually requires routine diagnosis, stimulation diagnosis, and symptomatic diagnosis, as well as identification of other disorders such as facial tics and trigeminal neuralgia. 1. Diagnostic Criteria: The diagnosis of Major Syndrome is usually made by routine tests, such as electroencephalography (EEG), electromyography (EMG), and, if necessary, mammograms and x-rays, computed tomography (CT), and magnetic resonance imaging (MRI), to rule out other mastoid and cranial disorders. Common electrolyte, micronutrient or biochemical tests are also useful to differentiate the disease from others. Stimulation of the supraorbital nerve can also be used for diagnostic purposes, as well as for characteristic signs such as involuntary bilateral eyelid closure with symmetrical irregular contractions of the orofacial muscles. The condition will be aggravated under excitement or bright light, and will be lighter or even disappear when calm or after sleep. 2. Differential diagnosis: It can be differentiated from hysterical blepharospasm, habitual facial twitching, trigeminal neuralgia, facial muscle spasm, and brucellosis syndrome by the above mentioned routine tests, stimulation tests, and characteristic symptoms. As soon as Meijer syndrome is detected, one needs to go to the hospital for treatment.