Whether hepatitis B core antibody is positive needs treatment depends on the indicators of hepatitis B surface antigen, quantitative hepatitis B virus, glutamic transaminase, etc., as well as age, whether there is cirrhosis, liver fibrosis or family history of cirrhosis and liver cancer. 1. Simple hepatitis B core antibody is positive, hepatitis B surface antigen and hepatitis B virus are negative, suggesting that previous infection with hepatitis B virus has been cured and does not require treatment. 2. Hepatitis B core antibody, surface antigen and hepatitis B virus are all positive, suggesting hepatitis B virus infection, and if the alanine aminotransferase is elevated, other liver diseases can be ruled out and treatment is needed. 3. When hepatitis B surface antigen and hepatitis B virus can be detected, if the liver function is normal but there is already cirrhosis or liver fibrosis, treatment is also needed. If there is no cirrhosis or liver fibrosis, if you are older than 30 years old and have a family history of cirrhosis or liver cancer, or have extrahepatic manifestations of hepatitis B, you need to be treated in time. Hepatitis B core antibody positivity may be due to previous infection or ongoing infection, and requires consultation with the Department of Infectious Diseases, complete relevant examinations, and treatment under the guidance of specialists.