Sprained ankle should be individualized according to the specific degree of injury, including rest and recuperation, hot and cold compresses, medication, and if the sprain is serious, it should be examined in a timely manner and treated with surgery. 1. Rest and recuperation: after ankle sprain, avoid activities, rest immediately to prevent secondary injury, and can elevate the lower limbs to promote venous return and reduce swelling. 2. Hot and cold compresses: within 72 hours of ankle sprain, intermittent ice or cold compresses should be applied to reduce the symptoms of swelling and pain, and after more than 72 hours, local hot compresses to improve blood circulation. 3. Medication: If there is obvious swelling and pain after the ankle sprain, you can take the medication such as oral relaxation tablets, blood circulation and pain relief capsules, or you can give non-steroidal painkillers, such as celecoxib tablets, meloxicam tablets and so on, which are helpful for relieving the symptoms. 4. Surgery: If the sprain is more serious, local deformity and activity limitation, we should take film or MRI examination in time, if there is ligament tear or ankle fracture dislocation, we can take surgical repair or internal fixation treatment. After the ankle sprain, through rest, local cold compresses and other symptoms can not be improved and relieved, should be timely consultation standardized treatment, to avoid delaying the condition. The use of drugs need to follow the doctor’s advice.