Panic and palpitations around 5pm every day may be due to arrhythmia, hypoglycemia, neurosis, gastrointestinal disorders and so on, and patients should seek medical attention in time. 1. cardiac arrhythmia: irregular, fast or slow heartbeat syndrome caused by the heart’s electrical conduction disorder, the patient will have a panic attack at about 5:00 p.m. every day, sweating, fatigue, palpitations, etc., and can be treated with medicines such as metoprolol, propafenone, and so on. 2. Hypoglycemia: palpitations, sweating, hunger and other symptoms caused by the decrease of glucose level in the blood, patients may have palpitations around 5:00 p.m., patients can be given glucose supplementation, and serious cases need to be treated with symptomatic anti-arrhythmic therapy with lidocaine. 3. Neurosis: a series of mental illnesses and disorders mostly seen in middle-aged and elderly women. Such people will have symptoms such as anxiety, excessive worry, tightness in the chest, and palpitations around 5 pm. Patients should keep their mood happy and take appropriate exercise. 4. Digestive tract diseases: gastroesophageal reflux disease (GERD), gastritis, etc. can also cause patients to have panic attacks and palpitations around 5 p.m. Every day, GERD is mostly caused by postprandial reflux, and patients should consult a doctor in time to get a clear diagnosis and treatment. All of the above drugs should be used under the guidance of a doctor.