Yellowing at the base of the eye may be caused by cholestasis, jaundice, and local inflammatory diseases. 1. Cholestasis: Abnormal liver function, cirrhosis, hepatitis, gallbladder problems, etc., can lead to cholestasis and the manifestation of yellowing of the sclera. 2. Jaundice: elevated bilirubin concentration in the blood causes yellowing of the sclera, skin, mucous membranes, and other tissues and body fluids. 3. Local inflammatory diseases: chronic inflammation, such as chronic conjunctivitis and chronic blepharitis, easily lead to conjunctival congestion, conjunctival vasodilatation, and conjunctival lipid metabolism abnormality, resulting in yellowing of the eyeballs and yellowing of the conjunctiva. There are many other causes of yellowing at the base of the eye, such as allergen irritation and ophthalmic diseases. Therefore, it is recommended to go to the hospital in time to follow the doctor’s instructions for examination and treatment of yellowing at the bottom of the eyeballs.