The antidote for organophosphorus pesticide poisoning is cholinesterase revitalizing agent, and the representative drugs are iodophosphorodine, chlorophosphorodine, bisphosphorodine, etc., and antagonists such as atropine. The mechanism of toxicity of organophosphorus pesticides is mainly the combination of organophosphorus and cholinesterase, so that cholinesterase is inactive, leading to excessive accumulation of acetylcholine, resulting in clinical symptoms. The main function of using cholinesterase revitalizing agent is to restore the function of cholinesterase. But in the clinical rescue of organophosphorus pesticide poisoning in addition to the use of antidotes, there are cholinergic receptor antagonists, mainly for the antagonism of acetylcholine accumulation caused by the M and N-like symptoms, representative of the drug has atropine. For organophosphorus pesticide detoxification, the use of atropine needs to reach atropine. But the clinical rescue of organophosphorus pesticide poisoning in addition to the use of antidotes, the preliminary timely removal of pesticide residues, including emetic, gastric lavage, diarrhea need to be carried out as soon as possible to minimize the toxic residues.