The most common causes of ankle pain are ankle sprain, osteoarthritis, rheumatoid arthritis, etc. If the patient’s symptoms persist, it is recommended to seek medical attention in time. 1. Ankle sprain: If the ankle is sprained, the patient’s local muscles and ligaments can cause different degrees of damage, resulting in pain and swelling of the ankle joint, and in severe cases, ankle fracture may also occur, which requires a timely visit to the hospital for radiographic examination. 2. Osteoarthritis: If osteomalacia occurs in ankle joint, it may be accompanied by degenerative changes of articular cartilage, which is usually related to heredity, trauma and other factors, and the patient will have pain in ankle joint, and in severe cases, deformation of joints may also occur. 3. Rheumatoid arthritis: Patients with rheumatoid arthritis will experience swelling and pain at the ankle joint when inflammation strikes, which is an autoimmune disease caused by the immune system’s wrongful attack on normal joints. Causes of bone pain in the back of the foot and ankle are more causes, but also may be related to lumbar disc herniation, gouty arthritis, infection, tumors and other diseases, if the symptoms continue to be unrelieved, it is recommended to go to the hospital in a timely manner by the doctor to find out the cause of the disease, and targeted treatment.