There is no specific medicine to remove yellow sputum. Yellow sputum is commonly caused by bacterial infection, and it is necessary to apply antibiotics such as amoxicillin to clarify the bacterial infection, or apply sputum transforming drugs such as carboxymetholestane to treat it, and symptomatic treatment. In addition, yellow sputum can be seen in a variety of respiratory diseases such as pneumonia, acute exacerbation of chronic obstructive pulmonary disease, etc. It is recommended to clarify the cause of the disease under the guidance of a doctor to treat the cause. 1. Antibiotics: yellow sputum is commonly caused by bacterial infections, sputum culture and drug sensitivity results are needed to guide the application of antibiotics, such as cefoperazone, cefepime, amoxicillin and other drugs, minors are generally prohibited levofloxacin and other quinolones. 2. Phlegmolytic drugs: When a person coughs up yellow sputum and pus, the secretion can be diluted through the application of phlegmolytic drugs, so that it is easy to be discharged, such as aminoglutethimide hydrochloride, carboxymethyl stannum and so on. When a person coughs yellow phlegm for a long time without relief or with fever and other symptoms, should be timely to the hospital, complete the relevant laboratory tests to clarify the cause of the disease, under the guidance of a professional physician to use medication, and pay attention to drink more water, pay attention to rest.