Recurrence of complete hyperemesis gravidarum refers to the development of localized complete hyperemesis gravidarum lesions, often with elevated tumor markers. Complete hyperemesis gravidarum is a relatively common disease in the clinic, and patients can often be cured after purging surgery combined with chemotherapy, but there is still the possibility of recurrence. After the treatment, patients should check the ultrasound, HCG and other indicators on time. If the patient has abnormal vaginal bleeding, abdominal pain, uterine enlargement and pseudo-pregnancy symptoms, and the HCG decreases but rises again or continues to rise, timely imaging tests, such as ultrasound, CT, etc., should be carried out to assess whether there is recurrence or even metastatic lesions, and timely chemotherapy can often achieve a better therapeutic effect. Therefore, the prognosis of most cases of complete hyperemesis gravidarum is better if the recurrent lesions are detected and treated in time after treatment.