Trimethoprim and Halomethasone do not exist which one is better to use, each has its own characteristics and clinical indications. 1. Trimethoprim cream: it is a compound preparation containing miconazole, trimethoprim and neomycin, which is suitable for eczema, contact dermatitis, seborrheic dermatitis, neurodermatitis, tinea corporis, tinea cruris, tinea cruris, tinea pedis and other diseases. Adverse reactions: occasional allergic reactions, skin burning, itching, pins and needles sensation, prolonged use can cause skin atrophy, hyperpigmentation, hirsutism. Contraindications are not clear. 2. Halometasone cream: it belongs to glucocorticoid drugs and is used for non-infectious inflammatory skin diseases that are effective in glucocorticoid treatment, such as seborrheic dermatitis, contact dermatitis, atopic dermatitis, local neurodermatitis, coin dermatitis and psoriasis vulgaris. Adverse reactions: Occasional symptoms include localized burning sensation and itching; rare adverse reactions are dry skin, erythema, skin folliculitis, and acne. Contraindications: prohibited for those who are allergic to the drug; prohibited for bacterial and viral infectious dermatoses; prohibited for fungal dermatoses, syphilis, rosacea, acne vulgaris. The appearance of skin diseases first go to the hospital for examination, the drug needs to be used under the guidance of a professional doctor.