Sandworm bites foot ulceration and pain and itching can choose topical or oral antibiotic drugs, antihistamines, glucocorticoid drugs treatment, such as miconazole, amoxicillin, loratadine, dianabed and so on. 1. Antibiotic drugs: If the patient is inadvertently bitten by sandworms on the feet, the skin is ulcerated, painful and itchy. In order to prevent infection, patients can use topical antibiotics such as metronidazole, mupirocin, fusidic acid. Or with oral, such as amoxicillin, cefuroxime and so on. Can effectively prevent infection and improve the symptoms of the disease. 2. Antihistamine drugs: If the patient has severe itching symptoms, you can take oral loratadine, cetirizine and other antihistamines to relieve the symptoms. 3. Glucocorticosteroids: patients can also use topical glucocorticosteroids, such as beclomethasone propionate, dianabed and so on, avoiding direct use on the skin ulcers. If the disease is serious, you can also take oral dexamethasone, prednisone and other glucocorticoid drugs. Patients should use medication under the guidance of a doctor, do not use medication without authorization, in order to avoid damage to health.