There is currently no five-combination therapy for H. pylori, and four-combination therapy is recommended. Quadruple therapy is mainly a method of treating H. pylori infection with a combination of four drugs, including a proton pump inhibitor, two antibiotics, and a bismuth agent. Commonly used proton pump inhibitors include omeprazole, rabeprazole, pantoprazole and so on. Commonly used antibiotics include amoxicillin, clarithromycin, levofloxacin, and metronidazole. Commonly used bismuth agents include bismuth potassium citrate, colloidal bismuth pectin, etc. After the eradication of H. pylori, the carbon 13 or carbon 14 breath test can be rechecked 1 month after stopping the medication, and most of the infections can be effectively eradicated. In addition, it is recommended that patients use quadruple therapy under the guidance of a doctor, and should not use it privately.