Acute pericoronitis is an inflammation of the soft tissue surrounding the crown of a wisdom tooth (i.e., third molar) when eruption is incomplete or obstructed. Usually, the decision of whether the diseased tooth can be extracted during the acute inflammatory period should be based on a comprehensive consideration of the patient’s systemic condition (e.g., absence of sepsis) and the ease of surgery (size of trauma). If the patient’s general condition is poor or the surgery is complicated and the damage is great, the extraction may aggravate or spread the inflammation and should be suspended; on the contrary, if the patient’s general condition is good and the surgical damage is small, the extraction of the focal tooth under the effective control of antibacterial drugs at this time is conducive to the drainage of the abscess, so that the severe pain is rapidly relieved and the inflammation can be controlled and rapidly improved or cured. Generally speaking, the diseased tooth itself is the focus of infection, which is both the source of infection and the culture base of bacteria. Through the infiltration of inflammatory cells, it will cause local capillary congestion and increase the headache. If we can seize the opportunity of treatment, improve anesthesia and surgical methods, extract the focal tooth that can no longer be saved in time, and reduce the local tissue pressure and toxic reaction, it will help to limit the inflammation, which can shorten the course of the disease and reduce the complications. On the other hand, if the stage of inflammation development is overly considered, and the tooth extraction is considered painful and inappropriate during the acute inflammation period, allowing the inflammation to continue to develop, destroying the surrounding tissues, forming fistulas in the oral cavity and skin, and even forming diffuse osteomyelitis and sepsis, the disease will be delayed and even life-threatening. At the same time, even if a large number of sensitive antibacterial drugs are used, but because the lesion has not gone, it can only control the acute inflammation, so that it becomes chronic, and once encountered with a decline in resistance, the infection will again acute attacks. In this way, drug damage to the liver arises. As the saying goes, a toothache is not a disease, but a pain that really kills. The only way to effectively control the inflammation and resolve the pain is to remove the diseased tooth as soon as the physical condition allows.