Sleeping hand numbness woke up immediately relieve the main reasons to consider include physiological factors, transient ischemic attack, carpal tunnel syndrome and so on. 1. Physiological factors: when sleeping, if the hand is compressed by the body and transient ischemia and hypoxia, there will be hand numbness woke up symptoms. When the pressure is lifted, the blood flow will return to normal, and the symptoms of hand numbness will also return to normal. 2. Transient ischemic attack: at the onset of the patient will appear to sleep with hand numbness, but the duration is shorter, the patient has underlying diseases, such as diabetes mellitus, hypertension and so on. Mainly manifested as a transient vertigo, eye movement abnormalities, etc., there can be localized numbness of the body, usually for a short period of time, there is no formation of foci. 3. Carpal Tunnel Syndrome: When the median nerve, which innervates the palmar sensation of the hand, passes through the wrist, the narrow carpal tunnel is compressed and induces symptoms. Numbness or pain is often felt in all three fingers and is most severe in the middle finger. The disease can occur unilaterally or bilaterally, and the symptoms are most severe at night or early in the morning, and can be relieved by shaking the wrist appropriately. Numbness in the hands after waking up may also be related to other problems, if frequent episodes should go to the neurology department of the hospital to clarify the cause of the disease, under the guidance of the doctor’s treatment.