Rough prostate can be caused by prostatitis or prostate cancer, which can be treated with medication such as levofloxacin or surgery. 1. Prostatitis: Roughness of the prostate may be caused by prostatitis, which can be treated with broad-spectrum antibiotics such as levofloxacin, norfloxacin and amoxicillin under the guidance of a doctor. 2. Prostate Cancer: Roughness of the prostate gland may also be caused by prostate cancer, which requires timely medical consultation and treatment, and surgical treatment after diagnosis, such as laparoscopic prostatectomy. To summarize, prostate roughness is not excluded from other causes, it is recommended to go to the hospital as soon as possible to do the examination, according to the cause of timely treatment.