The occurrence of chronic urticaria may be related to allergy, chronic hidden infection, mental factors, etc. Its treatment includes causative treatment and symptomatic treatment, and the symptomatic treatment is based on medication. Due to the different physical and medical conditions of individuals, there is no such thing as the best treatment method. 1. Causal treatment: chronic urticaria may be related to repeated stimulation of allergens, need to try to find the causative factors and avoid re-exposure. It may be related to the existence of chronic infection foci in the body, such as cholecystitis, etc., need to improve the relevant examination, and actively treat the primary disease. May be related to the mental state, need to adjust in time, keep a good mood. 2. Symptomatic treatment: local topical glycerine lotion, zinc oxide ointment and other antipruritic agents, mometasone furoate, hydrocortisone butyrate and other glucocorticosteroid ointment, pimecrolimus and other calcium-regulated phosphatase inhibitors. If necessary, can be combined with oral antihistamines such as loratadine, cetirizine and other drugs. It is recommended that chronic urticaria go to the regular hospital in time, by the doctor to determine the cause of targeted treatment. Drugs need to be used in accordance with medical advice.