Blood in urine, i.e. bleeding during urination, hematuria, can be caused by many diseases such as urological diseases, blood diseases, drug damage, etc. It is not necessarily a symptom of advanced bladder cancer. Usually, the initial symptom of most bladder cancers is hematuria, which is often manifested as painless, intermittent, hematuria throughout the whole process of naked eye. There are also a few bladder cancers that firstly present bladder irritation symptoms such as frequent urination, urgency, painful urination and difficulty in urination without obvious hematuria in the naked eye. Blood in urine can also be caused by many diseases, such as urological diseases commonly include glomerulonephritis, urinary tract infection, urinary polyps, congenital malformations of urinary system and stones, tuberculosis, tumors, etc. Hematological diseases, such as aplastic anemia, thrombocytopenic purpura, etc., and drug damages, such as cyclophosphamide-induced hemorrhagic cystitis, heparin, and anticoagulant, such as warfarin, etc., can also appear hematuria. Therefore, blood in urine is not necessarily a symptom of advanced bladder cancer. If you find blood in urine when urinating, you need to go to the hospital for examination to find out the cause of the disease and have reasonable treatment under the guidance of physician to avoid delaying the condition.