Callus, also known as callus, is a thickening of the stratum corneum caused by long-term pressure and friction of the skin, mostly occurring in the palms of the hands, soles and other parts of the foot, manifested as a waxy or yellow, localized thickening of the plaque. Patients with calluses on the soles of the feet can remove them through general treatment, medication and physical therapy. 1. General treatment: patients should do a good job of foot care in general, try to avoid friction and pressure. Usually wear comfortable and breathable shoes and socks, and regularly use warm water to soak the feet or use a towel to apply hot compresses, so as to soften the local keratin. 2. Medication: patients can use salicylic acid ointment, vitamin A acid ointment, urea ointment and other topical medications under the guidance of a doctor, which can play a role in dissolving and removing keratin. The above drugs should be used under the guidance of a doctor, patients can not be used on their own, so as not to delay the condition. 3. Physical therapy: patients can take liquid nitrogen freezing to treat calluses, through the cold effect of tissue necrosis. In addition, laser treatment can also use the photothermal effect of callus gasification, to help improve foot symptoms. Calluses on the soles of the feet and the need for treatment of patients should go to the hospital in a timely manner, under the guidance of the doctor for formal treatment.