Anti-ssa antibody positivity can be turned negative, and as long as reasonable and effective treatment is adhered to, this antibody can be completely turned negative, which is only an antibody in the anti-ENA series. It is usually present alone or in combination with anti-ssb antibodies. It is usually found in connective tissue diseases, such as dry syndrome, systemic lupus erythematosus, rheumatoid arthritis, scleroderma, and mixed connective tissue diseases, and usually when it appears, neonatal lupus and congenital atrioventricular block can occur, and it is often associated with symptoms of vasculitis, lymph node enlargement, leukopenia, photosensitivity, some skin damage, purpura, etc. After effective treatment, this antibody can turn negative after effective treatment.