Gliomas are classified as primary and secondary based on tumor origin, and mutant and wild-type based on glioma biologic behavior. The difference between the two is in the age of onset, medical history, and mode of development. Primary type refers to the glioma as soon as it is found, and secondary type refers to the glioma that is not initially found and later evolves into glioma wild type and mutant type. 1. Age of onset: wild type is usually older than 55 years old, with a median age of onset of 62 years; secondary type is more common in young and middle-aged people, with a median age of onset of 44 years. 2. Medical history: wild-type has a shorter history, average four months, with a poorer prognosis and a median survival of less than 15 months; secondary-type has a longer history, average 15 months, with a better prognosis and a median survival of more than 24 months. 3. Pathogenesis: wild-type glioblastoma presents with glioblastoma features at the time of initial diagnosis, consistent with primary glioblastoma; secondary often accompanied by a history of lower-grade astrocytoma, consistent with mutant glioblastoma.