The first manifestation of magnesium sulfate poisoning is the weakening or even disappearance of the knee-jerk reflex.
Magnesium sulfate can promote defecation, has the effect of diarrhea, clinically commonly used in acute constipation, food or drug poisoning when cleaning the intestinal tract, or as a kind of anticonvulsant, used to reduce blood pressure, treatment of pre-eclampsia and eclampsia and so on.
Because the magnesium ions can inhibit the release of acetylcholine and block neuromuscular conduction, so that skeletal muscle relaxation, so when magnesium sulfate poisoning occurs the first will appear knee reflexes will be weakened or disappeared, with the passage of time, there may be respiratory depression or rapid heartbeat and other reactions.
If magnesium sulfate poisoning occurs, you should go to the hospital in time, under the guidance of the doctor to prevent life-threatening treatment.