The blood indicators of bone metastasis mainly consist of calcium ions and alkaline phosphatase. Bone metastasis is a relatively common situation in clinic, and the more common malignant tumors that are prone to bone metastasis include lung cancer, breast cancer, thyroid cancer, kidney cancer and prostate cancer, so patients with these diseases must pay attention to bone scanning examination to assess whether there is any metastatic phenomenon. 1. Calcium ion: bone metabolism indexes can reflect the speed of bone resorption and formation in the process of bone metastasis, suggesting the degree of bone destruction and repair. When the tumor metastasizes, the tumor cells will act on osteoblasts and osteoclasts, leading to the destruction of normal bone metabolism mechanism, abnormal increase of blood calcium ions and abnormal bone metabolism indexes. 2. Alkaline phosphatase: when bone metastasis occurs, the level of alkaline phosphatase will increase, which is positively correlated with the level of the lesion, and can be mainly used to evaluate the therapeutic effect. 3. Treatment mainly consists of bisphosphonate application, and local radiotherapy can be considered when necessary, which can also control the progression of the disease, prolong the survival period of the patient and improve the quality of life of the patient. Bone metabolism indexes have certain reference value in the early diagnosis of bone metastasis of lung cancer, but they can not be used as the gold standard of diagnosis, and the definitive diagnosis of bone metastasis still needs to rely on pathological examination.