The drugs that epileptic patients cannot take include imipramine, haloperidol (norfloxacin), fludioxonate (enoxacin), ciprofloxacin (ciprofloxacin), etc. The incidence of central nervous system toxicities caused by ciprofloxacin is 0.4% to 2.2%. The main side effects are dizziness, headache, anxiety, hand tremor, drowsiness, confusion, insomnia, hallucinations, epilepsy, etc. The treatment with ciprofloxacin 200 mg twice daily suddenly induced grand mal seizures on the 5th day of treatment, and a similar reaction occurred on the 7th day during the drip, which was not seen after stopping the drug. It is thought to be due to the drug blocking the binding of antiepileptic drugs to receptors in the brain, directly causing neurotoxicity. Recent studies have demonstrated that quinolones can inhibit the binding of the inhibitory transmitter γ-aminobutyric acid (GABA) to receptor sites in the brain, which increases excitability of the central nervous system, leading to spasms and induced seizures. Therefore, it is recommended to use these drugs with caution for any history of epilepsy.