The maximum number of times you can take antipyretic drugs within 24 hours is no more than four times, but five times is just one more time, and if the excess amount each time is not too big, it usually does not affect particularly. However, for people whose gastrointestinal tract is usually not so good, taking antipyretic drugs may cause irritation of the gastrointestinal tract, leading to gastritis and even peptic ulcers later. Another serious manifestation is the overdose of antipyretic drugs taken at one time and five times, in this case, the intake of NSAIDs will be excessive within 24 hours, which will increase the burden on the liver and may cause liver damage and, in particularly serious cases, liver failure. Also overdosing may cause more sweating if the fever is reduced, causing deficiency and a drop in blood pressure.