Vaccination is generally referred to as vaccination. A fever of 39.5° after vaccination requires fever-reducing medication, physical cooling, and prompt medical attention to address the cause of the illness. When the human body inoculated with a certain vaccine, will stimulate the immune system to produce the corresponding antibodies, at the same time antigen antibody produced by the immune response, it may lead to the vaccinee to appear 39.5 ° fever. In this case, fever-reducing medications should be taken under the guidance of a doctor to lower the body temperature to the normal range for treatment, such as aspirin tablets, ibuprofen tablets, celecoxib tablets and so on. At the same time can also be used through the use of warm water, alcohol rubbing the body for physical cooling, can be through the air evaporation of water will be part of the body heat away. Appropriate drinking warm salt water, replenish the body electrolytes, promote the discharge of metabolic waste, is conducive to the decline in body temperature. After vaccination, patients with a fever of 39.5 ° should go to the hospital in a timely manner, after clarifying the cause of the disease, combined with the specific symptoms of the patient to follow the doctor’s instructions for targeted treatment. The medication should be used under the guidance of a professional physician, and should not be used arbitrarily.