Patients with epilepsy have psychological and behavioral disorders, and even worse, they may resort to suicidal behavior. The suicide rate in the epileptic population is about 3-5 times higher than that of the normal population, with patients with temporal lobe epilepsy and complex partial seizures having an even higher rate of suicide, about 25 times higher than that of the normal population. Suicidal behavior in patients with epilepsy may be the result of a combination of factors. For example, the lesion disrupts the neurochemical structure, leading to neurotransmitter dysfunction; the ensuing psychological and family burdens, life conflicts, and a host of other problems after the onset of epilepsy amount to chronic stressful stimuli that trigger corresponding neurobiological responses; and may also be related to the patient’s depression and cognitive dysfunction. Depression and cognitive dysfunction in patients with epilepsy may have common neuropsychological mechanisms and therefore may cause similar psychopathological symptoms, including suicide. Therefore, families and society should pay increased attention to them to reduce suicidal behavior of patients.