Children with small blisters on the hands is very itchy, common disease factors are sweat herpes, tinea cruris, hand, foot and mouth disease, etc., the cause of different treatment methods are different, should promptly go to the hospital dermatology department, the common treatment methods are drug therapy (including oral medication and topical medication) and so on. Sweat herpes patients may appear finger blisters, and accompanied by different degrees of itching, burning sensation, can follow the doctor’s instructions for local use of glycerite and other drugs, but also oral cetirizine hydrochloride and other drugs to relieve the symptoms of itching, but also the use of prednisone and other hormone drugs, as appropriate. Small blisters on children’s hands may also be caused by ringworm. Antifungal drugs such as clotrimazole and cyclopyrrolidine can be used locally. In the case of hand, foot and mouth disease, the scope of herpes can involve the foot, mouth and other parts of the body, at this time the need for appropriate isolation treatment. If the child’s condition is mild, no special treatment, can be carried out at home for general symptomatic treatment, more can be self-healing. Children with small blisters on the hands is very itchy, the family should pay attention to, timely consultation, improve the relevant examination, and actively cooperate with the doctor’s treatment, the above drugs need to be used under the guidance of the doctor.