When inflammation occurs in the liver, elevated bilirubin occurs. When inflammation occurs in the liver, the production of some enzymes decreases and cannot combine with the indirect bilirubin in the blood, so that the uptake of indirect bilirubin in the blood is impaired. In another condition, the excretion of direct bilirubin is impaired after the inflammation of the liver, which is mainly manifested as an increase in direct bilirubin, commonly seen in bilious hepatitis. There is another type of hepatitis in which impaired bilirubin uptake and impaired bilirubin secretion occur simultaneously, and direct bilirubin and indirect bilirubin are elevated at the same time.