Warts on the back of the hand can be removed by physical therapy and medication. 1. Physical therapy (1) Cryotherapy: a common method, usually using liquid nitrogen to make the warts necrotic and fall off. (2) Laser therapy: commonly used in the clinic, the use of high-intensity laser removal. (3) Electrocautery therapy: Cauterize the warts. 2. Drug therapy (1) Topical drugs: retinoic acid drugs, such as retinoic acid ointment; 5-fluorouracil ointment; salicylic acid and so on. (2) Intradermal injection: procaine or interferon, vitamin D3 in the skin lesion injection. If you have warts on the back of the hand, you should consult a clinical professional doctor to determine the treatment plan and use the medication under the doctor’s guidance.