Small particles on both sides of the nose need to be treated according to the cause of the symptoms, usually using medication, sterile needle removal, laser treatment methods, common causes are acne, cornu rashes and so on. 1. Acne: If it is acne, it can be manifested as pimples, papules and pustules on the surface of the skin, etc. It can be treated with local topical retinoic acid cream, adapalene gel, fusidic acid ointment, etc. Oral medications, such as isotretinoin, can be combined with the treatment of severe cases, and all the above medications are associated with adverse reactions, and it is recommended that they be used under the supervision of a doctor. 2. Corns: excessive oil secretion on both sides of the nose and incomplete cleansing may induce fat grains, which appear as small yellowish-white particles on the surface of the skin covered with thin epidermis, and can be squeezed out to form globular particles. Generally, no treatment is needed. If there is a need for appearance, the small granules can be picked out with a sterile needle under the operation of a doctor, or they can be removed by using carbon dioxide laser treatment. Small particles on both sides of the nose may also have other causes, it is recommended to go to the hospital in time to improve the examination, to clarify the cause of the disease and then give targeted treatment.