Monkeypox is caused by infection with the monkeypox virus. Humans are infected with monkeypox virus mostly due to bites from infected animals or direct contact with blood, body fluids, or skin lesions of infected animals, and human-to-human transmission of monkeypox can also occur. Monkeypox virus originates in the tropical rainforest areas of central and west Africa, and in the past, monkeypox cases occurred mostly in Africa.With the advancement of global animal trade, in recent years, monkeypox infection cases are not limited to Africa.In mid-April 2003, an outbreak of monkeypox epidemic occurred in the United States, and 81 suspected and confirmed cases had been identified by mid-June of the same year.2022 Since May 2022, there have been related monkeypox infections in a number of countries in the U.K. and the U.S. The case of monkeypox infection has been reported in the United Kingdom and the United States since May 2022. There is currently no effective treatment for monkeypox, and contact with wild animals should be avoided in daily life, and disinfection and protection should be provided after contact to avoid infection.