Every morning at three or four o’clock in the morning stomach hidden pain is considered to be duodenal ulcer, abdominal cold, gallbladder stones, pancreatic disease and other disease factors caused. The doctor’s guidance is required to carry out targeted treatment, such as drug treatment, surgical treatment, and so on. 1. Duodenal ulcer: the pain of duodenal ulcer usually occurs at night or under the state of hunger. Omeprazole, lansoprazole and other acid-suppressing drugs can be used, aluminum sulfate and other drugs to protect the gastric mucosa, accompanied by Helicobacter pylori infection can be used in quadruple therapy, i.e., an acid-suppressing drug such as omeprazole + a bismuth such as bismuth pectin + two antibiotics such as metronidazole, amoxicillin and so on. 2. Abdominal cold: If you do not pay attention to keep warm at night, resulting in abdominal cold can also appear hidden pain symptoms. In such cases, local hot compresses can be applied to relieve the pain, and patients with severe diarrhea can consider using Montelukast to stop the diarrhea. 3. Gallbladder stones: when sleeping position changes, due to the stone displacement caused by embedded in the gallbladder duct can also cause pain; can be prescribed to take ursodeoxycholic acid treatment, the pain can be used when the pain is severe scopolamine analgesic, if necessary, can be surgical treatment. 4. Pancreatic diseases: such as acute and chronic pancreatitis, pancreatic cancer, etc., can also cause pain, can be given omeprazole, ustekin, etc., chronic pancreatitis can be given pancreatic enzyme preparations, surgical treatment. Pancreatic cancer, on the other hand, requires surgery, chemotherapy and other treatments. It is recommended to go to the hospital in case of hidden stomach pain at 3 or 4 a.m. every day, and ask the doctor to make a judgment and give a treatment plan.