Slightly high signal changes in the pallidum bilaterally are manifestations of MRI findings suggestive of bilirubin encephalopathy and carbon monoxide poisoning. The site of neurotoxic effect of bilirubin is highly selective, and the most common site is the pallidum of the basal ganglia. Cranial magnetic resonance imaging (MRI) is valuable in the diagnosis of bilirubin encephalopathy. Bilirubin encephalopathy in the acute stage of cranial MRI can appear bilateral pallidum symmetric T1-weighted high signal, weeks or months after the T1-weighted high signal gradually disappeared, back to normal; if in the corresponding parts of the presentation of T2-weighted high signal, that is, chronic bilirubin encephalopathy (kernel jaundice) changes. The change of T1-weighted high signal does not correlate well with the long-term prognosis of the child, and the T2-weighted high signal suggests a poor prognosis. Others, such as carbon monoxide poisoning and pigmentary degeneration of the substantia nigra and red nucleus of the pallidum, can present with pallid globe high signal. Pallid globe hyperintensities with clinical symptoms should be referred to a doctor for a definitive diagnosis.