Drug therapy is the most basic treatment for Parkinson’s disease, and it is very effective for symptom relief and control in the early stage, even when the disease has progressed to the middle and late stage, when the efficacy of drugs has diminished, drugs still play an irreplaceable role. Even if the dose of drugs is increased, the duration of effect is very short and the effect is limited, the patient is in great pain and most of the time in a drug-free state. At this time, patients need surgical means to eliminate abnormal excitation of nucleus pulposus and relieve symptoms, so they choose brain pacemakers to help patients prolong the duration of drug action, improve the patient’s symptoms when there is no drug action, reduce the dose of medication, reduce the side effects of drugs such as allodynia, and improve the quality of life. Therefore, the two treatments are not opposed to each other; medication is not meant to be taken without surgery, and surgery is not meant to be taken without medication. The best treatment for patients with intermediate and advanced Parkinson’s disease should be “Parkinson’s medication in one hand and a pacemaker in the other”.