Cough worsened at night, white sputum turned yellow sputum consider the combination of bacterial infection, need to use antibiotic treatment. Cough worsened at night, white sputum turned yellow sputum can be seen in acute upper respiratory tract infection, acute bronchitis, chronic bronchitis acute exacerbation, etc. At this time, you can go to the hospital to check the blood routine + C-reactive protein, white blood cells, neutrophils, C-reactive protein indicators are elevated suggesting that bacterial infections, the treatment mainly includes the following aspects: 1. anti-infection treatment: after clarifying the bacterial infection, penicillin and cephalosporin can be taken orally as prescribed by the doctor. 2. Symptomatic expectorant: oral expectorant drugs, such as aminobromine hydrochloride, acetylcysteine, etc., can be taken to dilute sputum so that it is easy to cough out. 3. General care: eat a light diet, pay attention to rest, drink more water, avoid exertion and getting cold again. If the cough worsens at night and the white sputum turns into yellow sputum, it is recommended to go to the respiratory medicine department of the regular hospital for a comprehensive assessment by a specialist doctor and then give the treatment plan.