The common causes of knee soreness at night are knee joint strain, osteoarthritis, osteoporosis, etc. Different treatments should be adopted according to different causes, and the treatments include general treatment, physiotherapy, traditional Chinese medicine treatment and surgery. 1. Knee joint strain: due to long time walking, standing or frequent strenuous exercise of the lower limbs during the daytime, which causes wear and tear of the knee joints and aseptic inflammation, causing knee soreness at night, the treatment includes bed rest, localized hot compresses, physiotherapy, etc. and oral non-steroidal drugs such as ibuprofen, etc. 2. Osteoarthritis: degeneration of cartilage, osteophytes and other degenerative changes can stimulate the knee joint, causing knee pain, usually pay attention to warmth, oral repair of cartilage drugs such as chondroitin sulfate. 3. Osteoporosis: at night due to osteoporosis decalcification is more obvious, knee acid, should strengthen the local warmth, the use of calcium such as calcium lactate, calcium gluconate and vitamin D, etc.. There may be other reasons why you can’t sleep at night with sore knees, so it is recommended that you go to the hospital in time to improve the examination, clarify the cause of the disease, and carry out standardized treatment under the guidance of the doctor.