In general, whether gastritis needs to take pathology should depend on the specific situation, if observed under gastroscopy mucosal thinning, submucosal vascular permeability or hyperplasia-like changes, it is recommended to take pathology under gastroscopy. Gastritis is an acute and chronic inflammatory disease caused by alcohol, trauma, Helicobacter pylori infection, autoimmune, mental and psychological factors acting on the gastric mucosa, which may manifest as vomiting of blood, black stools, nausea, vomiting, abdominal pain, abdominal distension, loss of appetite and other symptoms, and may be accompanied by systemic symptoms, such as fever and lethargy. According to the pathophysiological mechanism and common clinical symptoms of gastritis, it can be divided into acute gastritis, chronic gastritis and special types of gastritis. Acute gastritis gastroscopy can be manifested as transient acute lesions, such as congestion, edema, erosion, etc. Chronic gastritis can be divided into atrophic gastritis and non-atrophic gastritis according to pathology diagnosis, and chronic hypertrophic gastritis is categorized as special type of gastritis. If thinning of mucosa, translucency of submucosal blood vessels or hyperplasia-like changes are observed under gastroscope, it is recommended to take pathology under gastroscope, which can not only observe whether there is atrophy of gastric mucosa and reduction of glands, but also determine whether intestinal epithelial hyperplasia and atypical hyperplasia have occurred in gastric mucosa, which can help to screen whether there are precancerous lesions and cancerous lesions, so as to carry out targeted treatments. Whether to take pathology should follow the advice of specialized physicians.