Pain between fingers and palm every night may be caused by arthritis, stenosing tenosynovitis and other diseases, which can be treated by medication and surgery. 1. Arthritis: pain between the fingers and palm every night may be due to arthritis of the metacarpophalangeal joints, which can be treated with medications such as acetic clofenac and diclofenac as prescribed by the doctor. 2. Stenosing tenosynovitis: tendon sheath inflammation to a certain extent will proliferate, after proliferation caused by the narrowing of the fingers and palms of the hand can appear between the symptoms of pain, you can use such as celecoxib, meloxicam and other drugs to relieve pain. If the pain is not relieved by medication, it can be treated by surgical procedures such as small needle debridement, tenotomy and debridement. There may be other causes of pain between the fingers and the palm of the hand. If the pain persists without relief, you can consult a doctor to find out the cause of the pain and get targeted treatment.