Numbness of the mouth can be treated with various drugs such as nutritive nerve drugs, blood-activating drugs, antiplatelet drugs, glucocorticoids and so on. 1. Nutritional nerve drugs: when patients have peripheral neuropathy caused by numbness of the mouth, you can take vitamin B₁, vitamin B₁₂ tablets, glutamine tablets and other medications, which have the effect of nutritional nerve. 2. Blood-activating drugs: If the patient’s numbness is caused by cerebral infarction, he can take Ginkgo biloba leaf extract tablets and other medications to improve blood circulation disorders and alleviate the condition. 3. Antiplatelet drugs: When patients have ischemic stroke, it can cause numbness of the mouth. Antiplatelet drugs such as clopidogrel tablets and aspirin enteric-coated tablets can be taken orally to prevent repeated attacks. All drugs should be used under the guidance of a doctor. When the symptoms of numbness of the mouth occur for a long time, it is recommended that patients seek medical treatment in time and under the guidance of doctors.