High fibrinogen may be physiologic or related to a disease or pathologic condition. Fibrinogen is a protein synthesized by the liver that is associated with coagulation, is a precursor of fibrin, and is a coagulation factor. 1. Physiological: Fibrinogen may increase in the elderly with increasing age; it may also increase in pregnant women with prolonged gestation. 2. Disease or pathological state: Acquired fibrinogen increase, mostly seen in metabolic syndrome, hypertension, hyperlipidemia, obesity, also seen in pre-thrombotic state and thrombotic disease such as arterial / venous thrombosis, micro-thrombosis, etc.; other also seen in infection, trauma, surgery, tumors, burns, rheumatism and so on. Therefore, relying on a single test indicator, can not determine the specific cause, it is recommended to go to the regular hospital in a timely manner by a specialist to determine the cause.