If it is fresh leg thrombus, the best way to open it is thrombolysis + anticoagulation; if it is old venous thrombus, interventional surgery is needed to recanalize it. 1. Fresh leg thrombosis: For fresh lower limb thrombosis, vascular recanalization can be achieved after thrombolytic drug treatment, such as urokinase, streptokinase and other thrombolytic drugs. In addition, in order to prevent the thrombus from forming again, anticoagulant medication is needed for a period of time after thrombolysis, such as low molecular heparin subcutaneous injection anticoagulation or oral rivaroxaban tablets. 2. Old venous thrombosis: For the recanalization of old venous thrombosis in the lower limbs, the treatment is generally based on interventional surgery, such as percutaneous angiography + thrombectomy. Postoperative anticoagulant medication is also needed to prevent postoperative thrombosis. The best way to open the blood clots in the legs is based on the specifics of the blood clots, and requires specialized doctors to perform surgical treatment.