Lupus erythematosus nephritis type IV is already more serious, lupus erythematosus nephritis is divided into six types, lupus erythematosus nephritis type IV glomerular involvement has been more extensive, more than 50%, and accompanied by endothelial cell hyperplasia, as well as the immune complexes deposition under the endothelium. Lupus erythematosus nephritis type IV is very difficult to be completely cured, generally speaking, it can only be controlled by regular treatment with glucocorticosteroids, azathioprine, cyclophosphamide, tacrolimus and other medications, to avoid the deterioration of the disease. There is no accurate data to prove the survival time of patients with lupus erythematosus nephritis type IV, but as long as the patients actively follow the doctor’s instructions for standardized individual treatment, the survival time and quality of life of the patients can be improved to a certain extent. In conclusion, patients with lupus erythematosus nephritis type IV should pay great attention to the disease, go to the hospital in time and cooperate with doctors for active treatment.