Patient: Description of the condition (time of onset, main symptoms, hospital visited, etc.): I am 43 years old and found a lump in my left breast in October 2010, which was diagnosed as breast cancer in hospital pathology. “; immunohistochemistry results were: ER (+~++), PR (+~++), C-erbB-2 (+) <10%, Ki67 (+) Doing six-stage chemotherapy: the main drugs used were docetaxel, epirubicin, cyclophosphamide; after chemotherapy taking citrate tamoxifen tablets 10mg dose tablet Je, two capsules daily, now 4 months, at 3 months The endometrial thickness was about 1.1 cm, the uterine wall was smooth, and the left and right ovaries were enlarged, with a cystic cavity of about 2.4×1.1 cm and 2.0×1.3 cm, respectively, with clear borders and anechoic interior. At 4 months of age, the ultrasound showed a clear uterine size and shape, with a thickened endometrium of 1.8 cm and no significant abnormalities in the uterine area. The right ovary was enlarged and a cystic cavity of about 5.2 x 3.5 cm in size was seen with clear boundaries and an echogenic interior with slightly enhanced posterior echogenicity, and no significant mass or fluid accumulation was seen in the left adnexa. 1.Do I need endocrine therapy for my immunohistochemistry? 2.Can I continue to take tamoxifen? 3.If I need to continue endocrine therapy, are there any better alternative drugs with fewer side effects? 4.What kind of treatment do I need for my uterus and ovaries now? What drugs are available? Or a castration? 5. What is the best option for me in the end? Thank you, good people of the world. 1. Endometrial thickening is a side effect of tamoxifen. 2. Continue endocrine therapy and change the medication to toremifene. Use under doctor's guidance. 3. Hold off on the treatment of the uterus and ovaries and continue to observe.