Wrinkled skin on hands needs to be treated according to its causes, such as aging, malnutrition, prolonged soaking in water, eczema, etc. After diagnosis, general treatment, physical therapy, medication, etc. are chosen. 1. Ageing: Ageing will lead to a decrease in the secretion of sebaceous glands in the hands, dry and flaky skin, resulting in wrinkled skin on the hands. For treatment, patients can take good care of the skin on their hands and apply moisturizers to improve the phenomenon; if it affects the aesthetics, they can choose phototherapy. 2. Malnutrition: Malnutrition can lead to thinness, short stature and decreased skin elasticity, resulting in wrinkled skin on the hands. The treatment of this disease needs to be based on a balanced diet, supplement the lack of nutrients, avoid picky eating, partiality, anorexia and other behaviors. 3. Prolonged soaking in water: Prolonged soaking in water on the hands will cause the cells of the stratum corneum on the surface of the skin to absorb a large amount of water, resulting in the phenomenon of wrinkled skin on the hands. This condition can be relieved by avoiding prolonged soaking and does not require special treatment. 4. Eczema: especially chronic eczema, the cause of the disease is not yet clear, from acute eczema and other extension, often manifested as dry skin, flaking, cracking, which appeared on the hands of the phenomenon of skin wrinkles. Treatment of patients should do a good job of local skin care, in the doctor’s guidance of external glucocorticoids and other drugs, such as Dinaid cream, etc., if necessary, also need to take oral antihistamines and other treatments. It is recommended that patients with wrinkled skin on their hands exclude physical factors such as age, go to the regular hospital for a clear diagnosis in a timely manner, and take standardized treatment in accordance with the doctor’s instructions, and do not use drugs indiscriminately, so as not to lead to adverse consequences.