Does it hurt after knee replacement surgery? How long does it usually hurt? Decades ago, any surgery required the patient to be strong and endure for 48-72 hours afterwards, which is probably one of the reasons why some patients now fear surgery. But that is now history. Common pain relief measures after knee replacement include analgesic pumps, nerve blocks, and perioperative multimodal analgesia. We use perioperative multimodal analgesia. This approach includes preoperative medication to raise the pain threshold (that is, to reduce pain sensitivity); intraoperative local injection of anesthetic plus other drugs (similar to closure, also called a cocktail formula because of the application of a mixture of drugs); and postoperative continuous application of different types of pain medication to achieve complementary reinforcement. After surgery, the dosage of drugs is gradually reduced according to the patient’s response. Through this treatment, patients after knee replacement surgery are basically pain-free and can cooperate with leg lifting and bending knee exercises almost immediately after surgery. So, don’t worry about the pain after surgery.